The science of more good years

For cats

Heart health

Obstructive vs Non-Obstructive HCM in Cats: Why the Difference Decides the Treatment

Two cats, the same diagnosis, different diseases in practice. What outflow obstruction is, how the echo tells the forms apart, and why the split now decides which therapies even apply.

How Is HCM in Cats Treated? The Honest Map of Every Option

No medicine is licensed to treat feline HCM itself — but that sentence hides a landscape that has changed more in three years than in thirty. Every current option, with its evidence stated plainly.

Early Signs of Heart Disease in Cats — and the Ones That Are Emergencies

Cats hide heart disease better than any other patient. The subtle signs worth acting on, the sleeping breathing rate every owner should count, and the three presentations that mean emergency now.

HCM in Cats: Life Expectancy and What Changes It

How long a cat lives with hypertrophic cardiomyopathy depends mostly on the stage at diagnosis. An honest look at the numbers, the turning points, and what is and is not in an owner’s control.

Mavacamten for Cats: What It Is, and What the Evidence Shows

Mavacamten is the first drug class built for the mechanics of HCM — approved in human medicine, investigational in cats. What a myosin inhibitor does, who it might fit, and what is not yet known.

Heart Murmur in Cats: What It Means and What to Do Next

A murmur is a sound, not a diagnosis — many are harmless, and some cats with serious heart disease have no murmur at all. What the grades mean, which tests matter, and when to see a cardiologist.

Felycin-CA1 vs Compounded Rapamycin for Cats: An Honest Comparison

One is conditionally FDA-approved for subclinical HCM. The other is a vet-directed protocol available worldwide. Same molecule — here is which one fits which cat.

Rapamycin and HCM in Cats: What the Evidence Shows

Hypertrophic cardiomyopathy is the most common heart disease in cats and usually silent until it is advanced. Here is what research says about slowing its progression.

Cat Longevity: How to Add Healthy Years to Your Cat’s Life

Indoor cats now routinely live into their late teens. What determines whether those years are healthy ones — and what the science of feline aging says you can actually influence.

Kidney health

Chronic Kidney Disease in Cats: Slowing the Decline

CKD is the most common serious illness of older cats, and by the time symptoms appear most function is gone. What actually helps — and what is still being studied.

Care & buying guides

Where to Buy Rapamycin for Cats — and What It Should Cost

Rapamycin for cats is prescription-only. Here is how a legitimate prescription works, what the therapy costs, and the one case where an FDA-approved option should come first.

For dogs

Cancer

Carcinoma in Dogs: Types, Treatment, and the Real Role of Rapamycin

Carcinoma is one of the broad families of canine cancer. Here is what it is, how it is treated, and an honest account of whether rapamycin has a role.

Tumors in Older Dogs: Warning Signs and Where the Research Stands

Cancer is the leading cause of death in adult dogs. Here are the warning signs worth acting on early, the most common tumours, and an honest look at where longevity research fits.

Does Rapamycin Treat Cancer in Dogs? What the Studies Actually Show

Rapamycin targets a pathway that matters in cancer — but the largest trial in dogs found no survival benefit. Here is the honest state of the evidence, and where rapamycin does and does not fit.

Cancer in Dogs: Understanding the Risk and the Research

Cancer is the leading cause of death in adult dogs. What raises risk, which cancers dominate, what early detection looks like, and where mTOR research currently stands.

Aging & longevity

Why Is My Dog Slowing Down? Aging, Pain, and What Actually Helps

A slowing dog is the most common — and most misread — change owners report. The four causes to rule out before calling it age, and the interventions with real evidence behind them.

Signs of Aging in Dogs: What Is Normal, and What Is Not

Slowing on walks, greying muzzles, longer naps — some changes are normal aging. Others look like aging and are treatable disease. How to tell the difference, sign by sign.

How Long Do Dogs Live? Lifespan by Size, Breed, and What Moves It

Small dogs commonly live 12–16 years, giants 7–10. Why size sets the baseline, which factors an owner actually controls, and where aging research is trying to move the ceiling.

Rapamycin for Dogs: What the Science Actually Shows

Rapamycin is the most studied longevity molecule in veterinary medicine. Here is what the evidence shows about dosing, safety, heart health and healthy lifespan in dogs.

Care & buying guides

Where to Buy Rapamycin for Dogs — and How the Prescription Works

You cannot buy rapamycin for dogs over the counter — it is a prescription medicine. Here is how a legitimate prescription works, what it should cost, and what to avoid.

For both

Aging & longevity

mTOR and Aging: The Pathway Behind Longevity Medicine

One nutrient-sensing pathway decides whether cells grow or repair themselves. Understanding mTOR explains why a single molecule shows up across so many age-related diseases.

Care & buying guides

Sirolimus vs Rapamycin: They Are the Same Molecule

Sirolimus and rapamycin are two names for one drug. Here is why your vet may use either, where the names genuinely differ, and what that means for buying it for a cat or dog.

Rapamycin vs Longevity Supplements for Cats and Dogs: What Has Real Evidence

NAD boosters, spermidine, senolytics, fish oil — the pet longevity shelf is crowded. Here is an honest comparison of where supplements genuinely help and where rapamycin’s evidence is deeper.

Is Rapamycin Safe for Cats and Dogs? What the Trials Actually Found

The honest answer: at the low, intermittent doses used for longevity, rapamycin has been well tolerated in the published trials — with clear exceptions. Here is what the evidence shows and which animals should not take it.

Rapamycin Dosage and Side Effects in Pets: A Practical Guide

Longevity dosing is nothing like transplant dosing. How weight-based, intermittent protocols work, what side effects look like, and which animals are not candidates.